Interleukin-6 (IL-6) is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. Furthermore, It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. The human IL-6 is a single non-glycosylated polypeptide chain containing 183 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain (CD126), and the signal- transducing component gp130 (also called CD130). The human IL-6 shares about 40% a.a. sequence identity with mouse and rat IL-6 and it is equally active on mouse and rat cells.
| 货号 | 101-06 |
| 产地 | 北美 |
| 缩写 | rhIL-6 |
| 规格 | 10 μg, 100 μg, or 1 mg |
| 用途 | 科研 |
| 储存 | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8 °C for up to one week. For maximal stability, aliquot and store at -20 °C. Avoid repeated freeze/ thaw cycles. |
| 运输 | Gel pack |
