There are three mammalian isoforms of transforming growth factor-beta (TGF-β), namely TGF-β1, TGF-β2, and TGF-β3. These multifunctional cytokines signal through the same receptor and elicit similar biological responses. They play crucial roles in regulating cell proliferation, growth, differentiation, motility, and the synthesis and deposition of the extracellular matrix. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF-β3 is highly conserved across species, with mouse and human TGF-β3 demonstrating 100% sequence homology and cross-species activity. Recombinant Human TGF-β3 consists of two identical 112-amino acid polypeptide chains connected by a single disulfide bond and has a molecular weight of 25.0 kDa.
| 货号 | 105-53 |
| 产地 | 北美 |
| 缩写 | rhTGFb3 |
| 规格 | 10ug, 50ug, 500ug |
| 用途 | 科研 |
| 储存 | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| 运输 | Gel ice. |
