The dermal papillae are a highly active group of cells derived from the dermis mesenchyme. Located at the base of the hair follicles, the dermal papillae play a crucial role in hair growth cycle by inducing follicle development from the epidermis to produce hair fiber. Hair growth is tightly regulated by the epithelial-mesenchymal interaction of hair follicular cells, which involves various molecular pathways including BMP and Wnt signaling. A previous study showed that dermal papilla cells gradually lost their hair inductivity and proliferation capacity in long-term cultures. Continuous advancement in culture techniques will help provide better models for studying hair biology and hair reconstitution in regenerative medicine. HHDPC from ScienCell Research Laboratories are isolated from human scalp. HHDPC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HHDPC are characterized by their mesenchymal cell morphology and immunofluorescence with antibodies specific to fibronectin and/or CD105. HHDPC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HHDPC are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories. Recommended Medium It is recommended to use Mesenchymal Stem Cell Medium (MSCM, Cat. #7501) for culturing HHDPC in vitro.