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Interleukin-11 (IL-11) is encoded by the IL11 gene and is a member of IL-6 superfamily, distinguished based on their use of the common co-receptor gp130. It is a multifunctional cytokine first isolated from bone marrow-derived stromal cells. IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11Rα subunit and two molecules of the expressed cell signaling β subunit, gp130. The functions of IL-11 are that it directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production.
货号 | 101-11 |
产地 | 北美 |
缩写 | rhIL-11 |
规格 | 10 μg, 50 μg, or 1 mg |
用途 | 科研 |
储存 | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8 °C for up to one week. For maximal stability, aliquot and store at -20 °C. Avoid repeated freeze/ thaw cycles. |
运输 | Gel pack |
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