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人类阿尔茨海默病qPCR检测试剂盒

英文名:Human Alzheimer’s Disease qPCR Array Kit

货号:GK049

价格:$250

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ScienCell's GeneQuery™ Human Alzheimer’s Disease qPCR Array Kit (GQH-ALZ) facilitates gene expression profiling of key genes involved in Alzheimer’s disease onset and progression.  Alzheimer’s disease is a neurodegenerative disorder that results in progressive memory loss, disorientation, impaired thinking, and change in personality.  The disease exists in both early-onset and late-onset forms with progression characterized by amyloid plaque formation.  This kit focuses on late-onset Alzheimer’s although some early-onset susceptibility genes are included.  Brief examples of how included genes may be characterized are shown below:

  • Late-onset risk factors: APOE, CLU, CR1, PAXIP1, PICALM
  • Early-onset risk factors: PSEN1, PSEN2, APP, SORL1
  • Amyloid plaque formation: APP, APBB1, APBB2, RELN, BLMH
  • Disease progression/biomarkers: NOS3, GSK3B, HFE, PLAU, ACE

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that recognizes and efficiently amplifies a specific target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+and no DMSO); (ii) the primer set recognizes all known transcript variants of the target gene, unless otherwise noted; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis and gel electrophoresis. 

GeneQuery™ Human Alzheimer’s Disease qPCR Array Plate Layout* (8 controls in Bold and Italic)

 

1

2

3

4

5

6

7

8

9

10

11

12

A

A2M

APOE

CAT

DHCR24

GDNF

HMOX1

MAP2

NCSTN

PAXIP1

PSENEN

SOD1

β-actin

B

ACE

APP

CD40

DKK1

GPC1

IAPP

MAPK8

NGF

PICALM

PTGS2

SORL1

GAPDH

C

ACHE

BACE1

CDK5R1

DOCK3

GRIN2B

IDE

MAPT

NGFR

PIN1

RELN

SQSTM1

LDHA

D

ADAM10

BACE2

CLU

DPYSL2

GRN

IL1A

MARK1

NOS3

PLAU

S100B

SYP

NONO

E

APBB1

BDNF

CR1

DYRK1A

GSK3A

IL1B

MEOX2

NOTCH1

PLD3

SLC1A2

TARDBP

PPIH

F

APBB2

BLMH

CREB1

EIF2AK2

GSK3B

LDLR

MME

NQO1

PPP2R4

SLC6A4

UBB

GDC

G

APH1A

BPTF

CSNK1D

FPR2

HFE

LRP1

MPO

NTRK1

PSEN1

SNCA

UCHL1

PPC

H

APLP2

CASP2

CTSB

GAL

HM13

MAP1B

MSR1

OLR1

PSEN2

SNCB

VLDLR

NTC

 *gene selection may be updated based on new research and development

货号GK049
产地美国
缩写GQH-ALZ
规格One 96-well plate, one 20ul reaction per well
用途科研
储存4°C
运输胶冰


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